Tissue samples from surgically resected breast cancers and their corresponding clinical information were obtained from the First Department of Surgery, Sapporo Medical University Hokkaido, Japan and Department of Breast Surgery, The Cancer Institute Hospital of Japanese Foundation for Cancer Research Tokyo, Japan after obtaining written informed consents buy cialis generic online Patients affected by the new findings include women who, like most in the study, have early stage breast tumors measuring one to five centimeters that have not spread to lymph nodes; are sensitive to estrogen; test negative for a protein called HER2; and have a score of 11 to 25 on a widely used test that gauges the activity of a panel of genes involved in cancer recurrence